Transcriptomics,Multiomics

Dataset Information

5

Gene expression profiling of E18.5 FoxD1 Cre;Dicer and control embryonic kidneys


ABSTRACT: The aim of this study is to address the functional role of miRNAs in the FoxD1+ renal stroma progenitors and derivatives during embryonic kidney development. To achieve this, we generated transgenic mice that lack miRNAs in the renal stroma lineage (FoxD1 Cre;Dicer), and performed a microarray analysis on E18.5 whole kidneys to determine the transcriptional changes. 3 litters of E18.5 FoxD1 Cre;Dicer and control littermate kidneys were used for the microarray analysis. Each litter consists of kidneys pooled from 2 embryos per genotype for the RNA extraction.

OTHER RELATED OMICS DATASETS IN: PRJNA271018PRJNA271014S-EPMC6580251PRJNA271016

ORGANISM(S): Mus musculus  

SUBMITTER: Yu L Phua   Dr. Yu Leng Phua  Jacqueline Ho 

PROVIDER: E-GEOD-64441 | ArrayExpress | 2015-11-04

SECONDARY ACCESSION(S): GSE64441PRJNA271018

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-64441.additional.1.zip Other
E-GEOD-64441.idf.txt Idf
E-GEOD-64441.processed.1.zip Processed
E-GEOD-64441.sdrf.txt Txt
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Publications

Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.

Phua Yu Leng YL   Chu Jessica Y S JY   Marrone April K AK   Bodnar Andrew J AJ   Sims-Lucas Sunder S   Ho Jacqueline J  

Physiological reports 20151001 10


MicroRNAs are small noncoding RNAs that post-transcriptionally regulate mRNA levels. While previous studies have demonstrated that miRNAs are indispensable in the nephron progenitor and ureteric bud lineage, little is understood about stromal miRNAs during kidney development. The renal stroma (marked by expression of FoxD1) gives rise to the renal interstitium, a subset of peritubular capillaries, and multiple supportive vascular cell types including pericytes and the glomerular mesangium. In th  ...[more]

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