Transcriptomics

Dataset Information

297

Unique gene program of rat mesenteric arteries as revealed by Deep RNA Sequencing


ABSTRACT: This study used Deep RNA sequencing to define gene expression in the small resistance arteries and compare to a reference conduit artery, the aorta Methods: Deep RNA Sequencing (~90 million reads) was performed on 2 samples of adult SD rat mesenteric arteries and compared to that of 2 samples of aorta. Results: ~900 genes were identified that were expressed at least 2-fold difference between meseteric artery and aorta mRNA profiles of 2 samples of rat mesenteric artery and 2 samples of rat aorta were sequenced using Illumina HiSeq

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Anup Mahurkar   Amol Shetty  Rachael Dippold  Steven A Fisher  John Reho  Amol Carl Shetty 

PROVIDER: E-GEOD-64450 | ArrayExpress | 2015-07-13

SECONDARY ACCESSION(S): GSE64450SRP051483PRJNA271028

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Unique gene program of rat small resistance mesenteric arteries as revealed by deep RNA sequencing.

Reho John J JJ   Shetty Amol A   Dippold Rachael P RP   Mahurkar Anup A   Fisher Steven A SA  

Physiological Reports 20150701 7


Deep sequencing of RNA samples from rat small mesenteric arteries (MA) and aorta (AO) identified common and unique features of their gene programs. ~5% of mRNAs were quantitatively differentially expressed in MA versus AO. Unique transcriptional control in MA smooth muscle is suggested by the selective or enriched expression of transcription factors Nkx2-3, HAND2, and Tcf21 (Capsulin). Enrichment in AO of PPAR transcription factors and their target genes of mitochondrial function, lipid metaboli  ...[more]

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