Transcriptomics

Dataset Information

2

Expression data from AMPK deficient MLL-AF9 leukemia initiating cells and whole leukemia cells


ABSTRACT: Deletion of AMPK significantly extended the onset of leukemogenesis and depleted leukemia initiating cells (LICs). To identify how AMPK regulates LICs, we performed gene expression profiling of LICs isolated from AMPK wild type leukemic mice or AMPK-deficient leukemic mice. 4 groups were analyzed; 1) Whole leukemia (GFP+) from AMPK WT ( AMPKfl/fl) mice, 2) Whole leukemia (GFP+) from AMPK-deficient ( AMPKΔ/Δl) mice, 3) LICs=L-GMP (GFP+,lin-,c-kit+, CD16/32+,CD34+) cells from AMPK WT ( AMPKfl/fl) mice, 4) LICs=L-GMP (GFP+,lin-,c-kit+, CD16/32+,CD34+) cells from AMPK-deficient ( AMPKΔ/Δl) mice.

ORGANISM(S): Mus musculus  

SUBMITTER: Yusuke Saito   D Nakada  Y Saito 

PROVIDER: E-GEOD-64602 | ArrayExpress | 2015-01-01

SECONDARY ACCESSION(S): GSE64602PRJNA271397

REPOSITORIES: GEO, ArrayExpress

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