Transcriptomics

Dataset Information

32

Gene expression profiling of prefrontal cortices of mice subjected to acute and chronic social stress


ABSTRACT: In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays. The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system. We studied gene expression profiles of prefrontal cortices of male mice subjected to social stress of different durations: Comparisons included: acute stress (24 hours after single social stress episode) vs. acute control (unstressed), stress-8 days vs. control-8 days, stress-13 days vs. control-13 days, stress-13 days+5 days of rest vs. control-13 days+5 days of rest. For each comparison, we analyzed 3 biological replicates per group. Two of out of three biological replicates were further replicated in dye swap (final dye swap failed due to problem during microarray hybridization). Each biological replicate consisted of equal amounts of total RNA from 3 mice subjected to the same experimental condition.

ORGANISM(S): Mus musculus  

SUBMITTER: Adrian M Stankiewicz  Grzegorz R Juszczak   Pawel Lisowski   Artur H Swiergiel   Adrian Mateusz Stankiewicz   Marek Wieczorek   Joanna Goscik   Alicja Majewska    

PROVIDER: E-GEOD-64734 | ArrayExpress| 2015-01-10

SECONDARY ACCESSION(S): GSE64734PRJNA271746

REPOSITORIES: GEO, ArrayExpress

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Publications

Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.

Stankiewicz Adrian M AM   Goscik Joanna J   Swiergiel Artur H AH   Majewska Alicja A   Wieczorek Marek M   Juszczak Grzegorz R GR   Lisowski Paweł P  

BMC neuroscience 20141204


BACKGROUND: In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays. RESULTS: The most important finding was identification of hemoglobin genes (Hbb-b1, Hbb-b2, Hba-a1, Hba-a2, Beta-S) as potential markers of chronic social stress in mice. Expression of these genes was progressively increased in animals subjected to 8 and 13 days of repeat  ...[more]

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