Dataset Information


Lung expression data from highly pathogenic H5N1 virus infected and uninfected mice

ABSTRACT: Susceptible and Resistant mouse strain, e.g. DBA/2J and C57BL/6J respectively, were inoculated with a highly pathogenic H5N1 influenza A virus (A/Hong Kong/213/2003) for 72 hours. Differences in expression were analyzed and use to identify candidate genes and pathways that contributed to the difference in H5N1 pathogenesis in these two strains. Recombinant inbred BXD strains are derived from the DBA/2J and C57BL/6 parent and were used to identify genetic loci associated with resistant to H5N1 infection. Female 6-8 weeks old animals were inoculated with H5N1 virus or not and 72 hours later the lungs were obtained and immediately homogenized in Trizol. The extracted RNA was submitted for Affymetrix Gene expression arrays. Differences in gene-expression were determined and used to identify candidate genes and pathways that are important for disease severity and susceptiblity to H5N1 virus.

ORGANISM(S): Mus musculus  

SUBMITTER: Adrianus C Boon   Adrianus Cornelis Maria Boon  Richard J Webby 

PROVIDER: E-GEOD-64750 | ArrayExpress | 2015-01-08



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Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice.

Boon Adrianus C M AC   deBeauchamp Jennifer J   Hollmann Anna A   Luke Jennifer J   Kotb Malak M   Rowe Sarah S   Finkelstein David D   Neale Geoffrey G   Lu Lu L   Williams Robert W RW   Webby Richard J RJ  

Journal of virology 20090812 20

Despite the prevalence of H5N1 influenza viruses in global avian populations, comparatively few cases have been diagnosed in humans. Although viral factors almost certainly play a role in limiting human infection and disease, host genetics most likely contribute substantially. To model host factors in the context of influenza virus infection, we determined the lethal dose of a highly pathogenic H5N1 virus (A/Hong Kong/213/03) in C57BL/6J and DBA/2J mice and identified genetic elements associated  ...[more]

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