Transcriptomics

Dataset Information

35

Transcriptome analysis of lungs from six different mouse strains after infection with highly pathogenic H5N1 influenza A virus [set 2]


ABSTRACT: Susceptible (DBA/2J, 129/SvImJ, A/J) and Resistant (SM/J, C57BL/6J, Balb/cJ) mouse strain were inoculated with a highly pathogenic H5N1 influenza A virus (A/Hong Kong/213/2003) for 72 hours or not infected (control animals). Differences in expression were analyzed and used to identify candidate genes and pathways that contributed to the difference in H5N1 pathogenesis in these two groups of mice. Female 6-8 weeks old animals were inoculated with H5N1 virus or not and 72 hours later the lungs were obtained and immediately homogenized in Trizol. The extracted RNA was submitted for Illumina Gene expression profiling.

ORGANISM(S): Mus musculus  

SUBMITTER: Adrianus C Boon  Adrianus Cornelis Maria Boon   Richard J Webby    

PROVIDER: E-GEOD-64799 | ArrayExpress| 2015-01-17

SECONDARY ACCESSION(S): GSE64799PRJNA271892

REPOSITORIES: GEO, ArrayExpress

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Publications

H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load.

Boon Adrianus C M AC   Finkelstein David D   Zheng Ming M   Liao Guochun G   Allard John J   Klumpp Klaus K   Webster Robert R   Peltz Gary G   Webby Richard J RJ  

mBio 20110906 5


The genotype of the host is one of several factors involved in the pathogenesis of an infectious disease and may be a key parameter in the epidemiology of highly pathogenic H5N1 influenza virus infection in humans. Gene polymorphisms may affect the viral replication rate or alter the host's immune response to the virus. In humans, it is unclear which aspect dictates the severity of H5N1 virus disease. To identify the mechanism underlying differential responses to H5N1 virus infection in a geneti  ...[more]

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