Transcriptomics

Dataset Information

30

Transcriptome analysis of lungs from six different mouse strains after infection with highly pathogenic H5N1 influenza A virus


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Adrianus Cornelis Maria Boon   

PROVIDER: E-GEOD-64800 | ArrayExpress| 2015-01-19

SECONDARY ACCESSION(S): GSE64800PRJNA271891

REPOSITORIES: GEO, ArrayExpress

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Publications

H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load.

Boon Adrianus C M AC   Finkelstein David D   Zheng Ming M   Liao Guochun G   Allard John J   Klumpp Klaus K   Webster Robert R   Peltz Gary G   Webby Richard J RJ  

mBio 20110906 5


The genotype of the host is one of several factors involved in the pathogenesis of an infectious disease and may be a key parameter in the epidemiology of highly pathogenic H5N1 influenza virus infection in humans. Gene polymorphisms may affect the viral replication rate or alter the host's immune response to the virus. In humans, it is unclear which aspect dictates the severity of H5N1 virus disease. To identify the mechanism underlying differential responses to H5N1 virus infection in a geneti  ...[more]

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