Dataset Information


Hepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet

ABSTRACT: Xbp1 is an important regulator of unfolded protein response and lipid metabolism. Its dyregulation has been associcated in human NASH. Feeding a high fat diet with fructose/sucrose to mice causes progressive, fibrosing steatohepatitis. This study is to use RNA-Seq to identify differentially expressed genes in hepatic Xbp1 deficient mice livers fed with a high fat diet compared to controls. Hepatic Xbp1 deficient mice or flox controls were fed either regular chow or a high fat diet (n=4). Samples from each cohort were pooled into two replicates.

ORGANISM(S): Mus musculus  

SUBMITTER: Richard Green  

PROVIDER: E-GEOD-64824 | ArrayExpress | 2016-01-07



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Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet.

Liu Xiaoying X   Henkel Anne S AS   LeCuyer Brian E BE   Schipma Matthew J MJ   Anderson Kristy A KA   Green Richard M RM  

American journal of physiology. Gastrointestinal and liver physiology 20151015 12

Fatty liver is associated with endoplasmic reticulum stress and activation of the hepatic unfolded protein response (UPR). Reduced hepatic expression of the UPR regulator X-box binding protein 1 spliced (XBP1s) is associated with human nonalcoholic steatohepatitis (NASH), and feeding mice a high-fat diet with fructose/sucrose causes progressive, fibrosing steatohepatitis. This study examines the role of XBP1 in nonalcoholic fatty liver injury and fatty acid-induced cell injury. Hepatocyte-specif  ...[more]

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