Transcriptomics

Dataset Information

2

Chronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature [Methylation]


ABSTRACT: We performed genome-wide DNaseI hypersensitive site in FLT3-ITD and WT patient samples. We report corresponding gene expression, promoter methylation patterns of differential DHSs as well as differentially occupied TF binding motifs using surrounding DNAseI cut profiles. We examined association patterns of FLT3 ITD and WT AMLs and found that FLT3-ITD signaling is associated with common gene expression and chromatin signature. Examination of DNA methylation patterns in FLT3 ITD and WT AML via microarray study.

ORGANISM(S): Homo sapiens  

SUBMITTER: Anetta Ptasinska   Pierre Cauchy  Salam Assi  Maria R Imperato  Pierre Daniel Cauchy  Joaquin Zacarias-Cabeza  Peter Cockerill  Sally James  Sascha Ott  Constanze Bonifer  Jason Piper 

PROVIDER: E-GEOD-64934 | ArrayExpress | 2015-07-03

SECONDARY ACCESSION(S): GSE64934PRJNA272531

REPOSITORIES: GEO, ArrayExpress

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