Transcriptomics

Dataset Information

5

Intestinal development in two divergent chicken lines (X and Y)


ABSTRACT: The objective of this study was to investigate the impact of genotypic variation on both early microbial colonization of the gut and functional development of intestinal tissue. From two genetically diverse chicken lines intestinal content samples were taken for microbiota analyzes and intestinal tissue samples were extracted for gene expression analyzes, both at three subsequent time-points (days 0, 4, and 16). 1-day-old chicks (Lines X and Y) were housed in a floor pen system in which the chicks had ad libitum access to feed and water. At days 0, 4 and 16, 80 birds of each line X and line Y were sacrificed for tissue sampling, in total 240 birds per line. Subsequently, samples from these 80 birds were pooled in 8 pools of ten birds.

ORGANISM(S): Gallus gallus  

SUBMITTER: Dirkjan Schokker   M A Smits  J M Rebel  S A Vastenhouw 

PROVIDER: E-GEOD-65042 | ArrayExpress | 2016-01-14

SECONDARY ACCESSION(S): GSE65042PRJNA272779

REPOSITORIES: GEO, ArrayExpress

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Publications

Early life microbial colonization of the gut and intestinal development differ between genetically divergent broiler lines.

Schokker Dirkjan D   Veninga Gosse G   Vastenhouw Stephanie A SA   Bossers Alex A   de Bree Freddy M FM   Kaal-Lansbergen Lucia M T E LM   Rebel Johanna M J JM   Smits Mari A MA  

BMC genomics 20150528


Host genetic makeup plays a role in early gut microbial colonization and immune programming. Interactions between gut microbiota and host cells of the mucosal layer are of paramount importance for a proper development of host defence mechanisms. For different livestock species, it has already been shown that particular genotypes have increased susceptibilities towards disease causing pathogens. The objective of this study was to investigate the impact of genotypic variation on both early microbi  ...[more]

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