Dataset Information


Adiponectin-cre FTO flox/flox and FTO flox/flox mouse white fat tissues

ABSTRACT: Single nucleotide polymorphisms in intron 1 of the fat mass and obesity-associated (FTO) gene were found to be associated with an increased risk of adult obesity. Enhanced FTO expression in mice leads to hyperphagia, increased fat mass, and higher body weight. Neuronal-specific FTO–deleted mice have an identical lean body weight phenotype to global FTO-deleted mice. The physiological role of adipose FTO in the homeostasis of energy regulation remains to be elucidated. We used microarrays to elucidate the metabolic pathways that are regulated by FTO in the white fat. FTO flox/flox and Adiponectin-cre FTO flox/flox (AFO) mice were fed with chow diet. White fat tissues from epididymal adipose pad were harvested under ad lib condition for RNA isolation. Three independent pools of FTO flox/flox and AFO mouse white fat RNA were included in the study.

ORGANISM(S): Mus musculus  

SUBMITTER: Ming-Shien Wen   Ta-Sen Yeh  I-Chang Hsieh  Shian-Sen Shie  Delon Wu  Kuo-Chun Hung  Chao-Yung Wang 

PROVIDER: E-GEOD-65098 | ArrayExpress | 2016-07-03



Similar Datasets

2011-07-05 | E-GEOD-22857 | ArrayExpress
2011-07-05 | GSE22857 | GEO
2014-02-24 | E-GEOD-52830 | ArrayExpress
| GSE94098 | GEO
2016-01-05 | E-GEOD-74255 | ArrayExpress
2018-11-14 | GSE80481 | GEO
2012-01-10 | E-GEOD-27860 | ArrayExpress
2012-01-10 | GSE27860 | GEO
2013-06-15 | E-GEOD-47216 | ArrayExpress
2009-08-19 | E-MEXP-2201 | ArrayExpress