Transcriptomics

Dataset Information

3

Transcriptomics of circulating human eosinophils


ABSTRACT: Global expression pattern in eosinophils in various conditions such as eosinophilic asthma, hypereosinophilic dermatological diseases, parasitosis and pulmonary aspergillosis. Eosinophil were isolated from peripheral blood by FACS from 4 hypereosinophilic conditions: eosinophilic asthma (4 replicates), hypereosinophilic dermatological diseases (3 replicates), parasitosis (3 replicates) and pulmonary aspergillosis (4 replicates).

ORGANISM(S): Homo sapiens  

SUBMITTER: Doulaye Dembélé   Nicodème Paul  Anh Poirot  Nicolas Jung  Ghada Alsaleh  Seiamak Bahram  Béatrice Uring-Lambert  Fréderic de~Blay  Doulaye Dembele  Philippe Georgel  Cindy Barnig 

PROVIDER: E-GEOD-65239 | ArrayExpress | 2015-12-10

SECONDARY ACCESSION(S): GSE65239PRJNA273485

REPOSITORIES: GEO, ArrayExpress

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Publications

Circulating Human Eosinophils Share a Similar Transcriptional Profile in Asthma and Other Hypereosinophilic Disorders.

Barnig Cindy C   Alsaleh Ghada G   Jung Nicolas N   Dembélé Doulaye D   Paul Nicodème N   Poirot Anh A   Uring-Lambert Béatrice B   Georgel Philippe P   de Blay Fréderic F   Bahram Seiamak S  

PloS one 20151102 11


Eosinophils are leukocytes that are released into the peripheral blood in a phenotypically mature state and are capable of being recruited into tissues in response to appropriate stimuli. Eosinophils, traditionally considered cytotoxic effector cells, are leukocytes recruited into the airways of asthma patients where they are believed to contribute to the development of many features of the disease. This perception, however, has been challenged by recent findings suggesting that eosinophils have  ...[more]

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