Dataset Information


Gene expression data from LCMV-specific WT and Tcf7-/- follicular T helper cells

ABSTRACT: We did microarray experiments to elucidate the transcriptome changes due to TCF-1 deficiency in Tfh cells. These data clearly demonstrate that Tfh-associated genes were down-regulated in TCF-1-null Tfh cells, whereas Th1-associated signatures were up-regulated, indicating that TCF-1 initiates the Tfh fate by directly strengthening Tfh signatures while suppressing Th1-associated genes. We first sorted WT and TCF-1-null Tfh cells (2 samples per group, each sample was pooled from 4 mice) at day 8 after LCMV Armstrong infection. Then, we extracted RNA, which were subsequently sent to microarray analysis.

ORGANISM(S): Mus musculus  

SUBMITTER: Xinyuan Zhou   Yuzhang Wu  Lilin Ye 

PROVIDER: E-GEOD-65693 | ArrayExpress | 2015-07-24



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The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection.

Xu Lifan L   Cao Yi Y   Xie Zhunyi Z   Huang Qizhao Q   Bai Qiang Q   Yang Xia X   He Ran R   Hao Yaxing Y   Wang Haoqiang H   Zhao Tingting T   Fan Zhonglei Z   Qin Aijian A   Ye Jianqiang J   Zhou Xinyuan X   Ye Lilin L   Wu Yuzhang Y  

Nature immunology 20150727 9

Induction of the transcriptional repressor Bcl-6 in CD4(+) T cells is critical for the differentiation of follicular helper T cells (T(FH) cells), which are essential for B cell-mediated immunity. In contrast, the transcription factor Blimp1 (encoded by Prdm1) inhibits T(FH) differentiation by antagonizing Bcl-6. Here we found that the transcription factor TCF-1 was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute vir  ...[more]

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