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Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction.

ABSTRACT: Recent technological advances have made transcriptome sequencing (RNA-seq) possible in cells with low RNA copy number including platelets. Resulting studies have used RNA-seq in platelets isolated from healthy individuals to characterize the platelet transcriptome. However, platelets, possibly through gene expression changes, contribute to the etiology of and response to cardiovascular disease and events. To address this, we performed the largest human platelet RNA-seq analysis to date in 34 platelet samples: 16 ST-segment elevation myocardial infarction (STEMI), 16 non-STEMI (NSTEMI), and 2 controls. RNA-seq of platelet samples from 34 individuals: 16 with ST-elevation myocardial infarction (STEMI), 16 with non-STEMI, and 2 non-myocardial infarction controls

ORGANISM(S): Homo sapiens  

SUBMITTER: John D Eicher   Jane E Freedman   Nada Esa  Yanqin Yang  Jun Zhu  David D McManus  Yoshiyuki Wakabayashi  Andrew D Johnson  Olga Vitseva  Andrew Danner Johnson 

PROVIDER: E-GEOD-65705 | ArrayExpress | 2015-09-15



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Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction.

Eicher John D JD   Wakabayashi Yoshiyuki Y   Vitseva Olga O   Esa Nada N   Yang Yanqin Y   Zhu Jun J   Freedman Jane E JE   McManus David D DD   Johnson Andrew D AD  

Platelets 20150914 3

Transcripts in platelets are largely produced in precursor megakaryocytes but remain physiologically active as platelets translate RNAs and regulate protein/RNA levels. Recent studies using transcriptome sequencing (RNA-seq) characterized the platelet transcriptome in limited number of non-diseased individuals. Here, we expand upon these RNA-seq studies by completing RNA-seq in platelets from 32 patients with acute myocardial infarction (MI). Our goals were to characterize the platelet transcrip  ...[more]

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