Dataset Information


Imporatance of substantial weight loss for altering gene expression during intensive cardiovascular lifestyle modification

ABSTRACT: The objective of this study was to examine relationships between weight loss through changes in lifestyle and peripheral blood gene expression profiles. Substantial weight loss (-15.2+3.8%) in lifestyle participants was associated with improvement in selected cardiovascular risk factors and significant changes in peripheral blood gene expression from pre- to post-intervention: 132 unique genes showed significant expression changes related to immune function and inflammatory responses involving endothelial activation. In contrast, participants losing minimal weight (-3.1+2.5%) showed only minor changes in cardiovascular risk factors and markers of inflammation, and no changes in gene expression compared to non-intervention controls after 1 year. Weight loss (>10%) during lifestyle modification is associated with down-regulation of genetic pathways governing interactions between circulating immune cells and the vascular endothelium and may be required to successfully reduce CVD risk. A prospective nonrandomized trail was conducted over 1 year in participants undergoing intensive lifestyle modification to reverse or stabilize progression of coronary artery disease. Cardiovascular risk factors, inflammatory biomarkers, and gene expression as a function of weight loss were assessed in 89 lifestyle participants and 71 retrospectively matched controls undergoing usual care.

ORGANISM(S): Homo sapiens  

SUBMITTER: Gera L Jellema   Darrell Ellsworth  Fionnuala A McDyer  Darrell L Ellsworth  Kimberly A Mamula  Ryan van Laar  Heather L Blackburn  Nicholas S Costantino  Renata J Engler  Marina N Vernalis 

PROVIDER: E-GEOD-66175 | ArrayExpress | 2015-02-21



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