Transcriptomics

Dataset Information

42

Imporatance of substantial weight loss for altering gene expression during intensive cardiovascular lifestyle modification


ABSTRACT: The objective of this study was to examine relationships between weight loss through changes in lifestyle and peripheral blood gene expression profiles. Substantial weight loss (-15.2+3.8%) in lifestyle participants was associated with improvement in selected cardiovascular risk factors and significant changes in peripheral blood gene expression from pre- to post-intervention: 132 unique genes showed significant expression changes related to immune function and inflammatory responses involving endothelial activation. In contrast, participants losing minimal weight (-3.1+2.5%) showed only minor changes in cardiovascular risk factors and markers of inflammation, and no changes in gene expression compared to non-intervention controls after 1 year. Weight loss (>10%) during lifestyle modification is associated with down-regulation of genetic pathways governing interactions between circulating immune cells and the vascular endothelium and may be required to successfully reduce CVD risk. A prospective nonrandomized trail was conducted over 1 year in participants undergoing intensive lifestyle modification to reverse or stabilize progression of coronary artery disease. Cardiovascular risk factors, inflammatory biomarkers, and gene expression as a function of weight loss were assessed in 89 lifestyle participants and 71 retrospectively matched controls undergoing usual care.

ORGANISM(S): Homo sapiens  

SUBMITTER: Gera L Jellema  Darrell Ellsworth   Fionnuala A McDyer   Darrell L Ellsworth   Kimberly A Mamula   Ryan van Laar   Heather L Blackburn   Nicholas S Costantino   Renata J Engler   Marina N Vernalis    

PROVIDER: E-GEOD-66175 | ArrayExpress | 2015-02-28

SECONDARY ACCESSION(S): GSE66175PRJNA276017

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2014-06-03 | E-GEOD-46097 | ArrayExpress
2014-05-02 | E-GEOD-10306 | ArrayExpress
2015-04-18 | E-GEOD-67738 | ArrayExpress
| PRJNA276017 | ENA
2016-07-02 | E-GEOD-72462 | ArrayExpress
2008-03-01 | GSE10306 | GEO
2014-06-03 | E-GEOD-50800 | ArrayExpress
2010-12-17 | E-GEOD-18608 | ArrayExpress
| GSE67738 | GEO
2018-06-19 | E-MTAB-6903 | ArrayExpress