Transcriptomics

Dataset Information

0

Characterization of tumor extracellular vesicle RNA cargo


ABSTRACT: Comparative RNA profiling between tumor cells and their secreted extracellular vesicles. Results revealed enrichment in genes involved in cellular migration and metastasis in extracellular vesicles, in agreement with their role as mediators of tumor progression. Mice were orthotoplically transplanted with MDA-MB-231 Breast Adenocarcinoma cells. Cells and extracellular vesicles (EVs) from the resulting tumors were isolated. EVs were characterized by electron microscopy and Nanoparticle Tracking Analysis before total RNA isolation for comparative analysis with cellular RNA. Three biological replicates were analyzed in (technical) duplicate.

ORGANISM(S): Homo sapiens  

SUBMITTER: Thomas Würdinger   Raymond Schiffelers  Ronny Schäfer  Jordi Berenguer  Anoek Zomer  Michiel Pegtel  Elzo de Wit  Frederik Verweij  Carrie Maynard  Saskia I Ellenbroek  Jacco Van Rheenen  Jacco van Rheenen  Alwin Kamermans  Evelyne Beerling 

PROVIDER: E-GEOD-66488 | ArrayExpress | 2015-03-05

SECONDARY ACCESSION(S): GSE66488PRJNA277176

REPOSITORIES: GEO, ArrayExpress

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