Transcriptomics

Dataset Information

36

Characterization of tumor extracellular vesicle RNA cargo


ABSTRACT: Comparative RNA profiling between tumor cells and their secreted extracellular vesicles. Results revealed enrichment in genes involved in cellular migration and metastasis in extracellular vesicles, in agreement with their role as mediators of tumor progression. Mice were orthotoplically transplanted with MDA-MB-231 Breast Adenocarcinoma cells. Cells and extracellular vesicles (EVs) from the resulting tumors were isolated. EVs were characterized by electron microscopy and Nanoparticle Tracking Analysis before total RNA isolation for comparative analysis with cellular RNA. Three biological replicates were analyzed in (technical) duplicate.

ORGANISM(S): Homo sapiens  

SUBMITTER: Thomas Würdinger  Raymond Schiffelers   Ronny Schäfer   Jordi Berenguer   Anoek Zomer   Michiel Pegtel   Elzo de Wit   Frederik Verweij   Carrie Maynard   Saskia I Ellenbroek   Jacco Van Rheenen   Jacco van Rheenen   Alwin Kamermans   Evelyne Beerling    

PROVIDER: E-GEOD-66488 | ArrayExpress | 2015-03-06

SECONDARY ACCESSION(S): GSE66488PRJNA277176

REPOSITORIES: GEO, ArrayExpress

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