Transcriptomics

Dataset Information

307

RNA-Seq of DRG and dorsal cord after nerve injury


ABSTRACT: Genes are up and down regualted in DRG and spinal dorsal cord after peripheral nerve injury WT male adult with sciatic and femoral nerve transection 7 days, RNA was purified from ipilateral or contralateral L4-L6 DRGs or lumbar spinal dorsal cords

ORGANISM(S): Mus musculus  

SUBMITTER: Zhonghui Guan  

PROVIDER: E-GEOD-66619 | ArrayExpress | 2015-12-10

SECONDARY ACCESSION(S): SRP055912GSE66619PRJNA277465

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Although microglia have been implicated in nerve injury-induced neuropathic pain, the manner by which injured sensory neurons engage microglia remains unclear. We found that peripheral nerve injury induced de novo expression of colony-stimulating factor 1 (CSF1) in injured sensory neurons. CSF1 was transported to the spinal cord, where it targeted the microglial CSF1 receptor (CSF1R). Cre-mediated sensory neuron deletion of Csf1 completely prevented nerve injury-induced mechanical hypersensitivi  ...[more]

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