Transcriptomics

Dataset Information

0

Identification of mir-342-3p functionally associated with transcriptional activity of MYC in lung cancer


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Takashi Takahashi   

PROVIDER: E-GEOD-66760 | ArrayExpress | 2016-01-06

SECONDARY ACCESSION(S): GSE66760PRJNA277869

REPOSITORIES: GEO, ArrayExpress

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Publications

miR-342-3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer.

Tai Mei Chee MC   Kajino Taisuke T   Nakatochi Masahiro M   Arima Chinatsu C   Shimada Yukako Y   Suzuki Motoshi M   Miyoshi Hiroyuki H   Yatabe Yasushi Y   Yanagisawa Kiyoshi K   Takahashi Takashi T  

Carcinogenesis 20151018 12


Accumulating evidence indicates that altered miRNA expression is crucially involved in lung cancer development, though scant information is available regarding how MYC, an archetypical oncogene, is regulated by miRNAs, especially via a mechanism involving MYC cofactors. In this study, we attempted to identify miRNAs involved in regulation of MYC transcriptional activity in lung cancer. To this end, we utilized an integrative approach with combinatorial usage of miRNA and mRNA expression profile  ...[more]

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