Transcriptomics

Dataset Information

299

MAGE-A1 Promotes Proliferation, Migration and Invasion of Human Melanoma Cells through RNA-SEQ Analysis via Affecting C-JUN-IL8-ARHGAP29 Network


ABSTRACT: To define the role of MAGE-A1 in melanoma growth and metastasis, we performed RNA-seq analysis on MAGE-A1 overexpression (OE) and knockdown (KD) models in A375 human melanoma cell line. Our results revealed that overexpression of MAGE-A1 dramatically promoted proliferation, migration, and invasion of human melanoma cells in vitro and down-regulated of MAGE-A1 inhibited tumor cell proliferation and invasion. Furthermore, MAGE-A1 exerts its tumor promoting activity via activating including ERK-MAPK signaling pathway by RNA-seq analysis. mRNA profiles of MAGE-A1 over expression (OE), knockdown (KD), pcDNA-vector control, and pRNAT-scramble control in A375 cell line were generated using Ion torrent

ORGANISM(S): Homo sapiens  

SUBMITTER: yadong yang   Xiangdong Fang 

PROVIDER: E-GEOD-66859 | ArrayExpress | 2016-01-04

SECONDARY ACCESSION(S): GSE66859SRP056135PRJNA278118

REPOSITORIES: GEO, ArrayExpress, ENA

Similar Datasets

2016-01-05 | E-GEOD-64693 | ArrayExpress
2012-03-15 | E-GEOD-31534 | ArrayExpress
2014-08-01 | E-GEOD-59655 | ArrayExpress
2015-07-27 | E-GEOD-71012 | ArrayExpress
2013-05-30 | E-GEOD-35640 | ArrayExpress
2015-04-07 | E-GEOD-67617 | ArrayExpress
2014-10-18 | E-GEOD-62464 | ArrayExpress
2012-10-27 | E-MEXP-3443 | ArrayExpress
| GSE99466 | GEO
| GSE59183 | GEO