Transcriptomics

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MicroRNA expression profiles of distinct mouse mammary epithelial cell types


ABSTRACT: RNA samples were prepared from freshly sorted mammary cell subpopulations (MaSC/basal-enriched, luminal progenitor, mature luminal and stromal) from five sets of adult mice. High throughput RT-PCR was used to measure the global microRNA expression profiles of each cell subpopulation. The expression profiles were compared between cell subpopulations to gain insight into the regulation of lineage-restricted genes. High throughput RT-PCR profiling of microRNA expression in four mouse mammary cell populations. Samples were collected from pooled mammary gland tissue from a number of mice. Samples were collected at over five different times with tissue from independent sets of mice.

ORGANISM(S): Mus musculus  

SUBMITTER: Jane Visvader   Gordon K Smyth  Bhupinder Pal  Yunshun Chen  Geoff Lindeman 

PROVIDER: E-GEOD-67055 | ArrayExpress | 2016-02-20

SECONDARY ACCESSION(S): GSE67055PRJNA278812

REPOSITORIES: GEO, ArrayExpress

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Publications

Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits.

Pal Bhupinder B   Chen Yunshun Y   Bert Andrew A   Hu Yifang Y   Sheridan Julie M JM   Beck Tamara T   Shi Wei W   Satterley Keith K   Jamieson Paul P   Goodall Gregory J GJ   Lindeman Geoffrey J GJ   Smyth Gordon K GK   Visvader Jane E JE  

Breast cancer research : BCR 20150618


MicroRNAs (miRNAs) have been implicated in governing lineage specification and differentiation in multiple organs; however, little is known about their specific roles in mammopoiesis. We have determined the global miRNA expression profiles of functionally distinct epithelial subpopulations in mouse and human mammary tissue, and compared these to their cognate transcriptomes and epigenomes. Finally, the human miRNA signatures were used to interrogate the different subtypes of breast cancer, with  ...[more]

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