Transcriptomics

Dataset Information

4

MicroRNA expression profiles of distinct human and mouse mammary epithelial cell types


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Gordon K Smyth  

PROVIDER: E-GEOD-67056 | ArrayExpress | 2016-02-20

SECONDARY ACCESSION(S): GSE67056PRJNA278811

REPOSITORIES: GEO, ArrayExpress

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Publications

Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits.

Pal Bhupinder B   Chen Yunshun Y   Bert Andrew A   Hu Yifang Y   Sheridan Julie M JM   Beck Tamara T   Shi Wei W   Satterley Keith K   Jamieson Paul P   Goodall Gregory J GJ   Lindeman Geoffrey J GJ   Smyth Gordon K GK   Visvader Jane E JE  

Breast cancer research : BCR 20150618


MicroRNAs (miRNAs) have been implicated in governing lineage specification and differentiation in multiple organs; however, little is known about their specific roles in mammopoiesis. We have determined the global miRNA expression profiles of functionally distinct epithelial subpopulations in mouse and human mammary tissue, and compared these to their cognate transcriptomes and epigenomes. Finally, the human miRNA signatures were used to interrogate the different subtypes of breast cancer, with  ...[more]

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