Transcriptomics

Dataset Information

13

Array of CCR6+ ILC3 from the mesenteric lymph node of naïve C57BL/6 mice


ABSTRACT: CCR6+ innate lymphoid cells were sorted from the mesenteric lymph node of naïve C57BL/6 mice Cells were sort purified as lineage negative, CD127+ CD90.2+ CCR6+ ST2- 4 replicates were performed

ORGANISM(S): Mus musculus  

SUBMITTER: Gregory F Sonnenberg  

PROVIDER: E-GEOD-67076 | ArrayExpress | 2015-05-21

SECONDARY ACCESSION(S): GSE67076PRJNA278866

REPOSITORIES: GEO, ArrayExpress

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Publications


Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly understood. Here, we demonstrate that group 3 innate lymphoid cell (ILC3)-intrinsic expression of major histocompatibility complex class II (MH  ...[more]

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