Transcriptomics

Dataset Information

3

FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development


ABSTRACT: The Forkhead Box, FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown herein, granulosa cell tumor (GCT) formation. Coordinate depletion of the tumor suppressor Pten gene in the Foxo1/3 strain enhanced the penetrance and onset of GCT formation A direct comparison of ovarian granulosa cells from wild type d25 and FOXO/PTEN knockout granulosa cell tumors.

ORGANISM(S): Mus musculus  

SUBMITTER: Dagmar Wilhelm   JoAnne S Richards  Yi A Ren  Diego H Castrillon  Zhilin Liu  Wei Zhou  Stephanie A Pangas 

PROVIDER: E-GEOD-67662 | ArrayExpress | 2015-06-17

SECONDARY ACCESSION(S): GSE67662PRJNA280594

REPOSITORIES: GEO, ArrayExpress

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Publications

FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.

Liu Zhilin Z   Ren Yi A YA   Pangas Stephanie A SA   Adams Jaye J   Zhou Wei W   Castrillon Diego H DH   Wilhelm Dagmar D   Richards JoAnne S JS  

Molecular endocrinology (Baltimore, Md.) 20150610 7


The forkhead box (FOX), FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown here, granulosa cell tumor (GCT) formation. Coordinate depletion of the tumor suppressor Pten gene in the Foxo1/3 strain enhanced the penetrance and onset of GCT formation. Immunostaining and Western blot analyses c  ...[more]

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