Transcriptomics

Dataset Information

183

Transcription profiling of human HeLa cells and MCF10A cells subject to EGF stimulation


ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE6783: Expression data from HELA cells subject to EGF stimulation; GSE6784: Expression data from MCF10A cells subject to EGF stimulation Experiment Overall Design: Refer to individual Series

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Tal Shay 

PROVIDER: E-GEOD-6786 | ArrayExpress | 2008-06-15

SECONDARY ACCESSION(S): GSE6786PRJNA99235

REPOSITORIES: GEO, ArrayExpress

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Publications


Signaling pathways invoke interplays between forward signaling and feedback to drive robust cellular response. In this study, we address the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events of growth factor signaling. Using epidermal growth factor receptor signaling as the major model system and concentrating on regula  ...[more]

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