Transcriptomics

Dataset Information

6

Furin deficiency efect on T cells


ABSTRACT: Analysis of T-cells lacking the proprotein convertase furin. Proprotein convertases promote the proteolytic maturation of proproteins. Furin is induced in activated T-cells. Results provide insight into the function of furin in T-cells. CD4+CD62L+CD44- naive, CD4+CD62L-CD44+ memory and CD4+CD25+FoxP3+ regulatory T cells were isolated from Fur flox/flox and CD4 cre Fur flox/flox mice. Naive T cells were activated via TCR. Total RNA was extracted from all cells and hybridized to Affymetrix microarrays.

ORGANISM(S): Mus musculus  

SUBMITTER: John Creemers   Zsuzsanna Ortutay  Csaba Ortutay  John J O´Shea  Anna Oksanen  Martha Quezado  Saara Aittomäki  Lili Xu  Ethan M Shevach  Marko Pesu  Nicolas Bouladoux  Ivan Fuss  Yasmine Belkaid  Wendy T Watford  Warren Strober  Lai Wei  Anton Roebroek  John Andersson 

PROVIDER: E-GEOD-67884 | ArrayExpress | 2015-08-05

SECONDARY ACCESSION(S): GSE67884PRJNA281111

REPOSITORIES: GEO, ArrayExpress

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Publications

Proprotein convertase FURIN regulates T cell receptor-induced transactivation.

Ortutay Zsuzsanna Z   Oksanen Anna A   Aittomäki Saara S   Ortutay Csaba C   Pesu Marko M  

Journal of leukocyte biology 20150429 1


Antigen emergence rapidly stimulates T cells, which leads to changes in cytokine production, cell proliferation, and differentiation. Some of the key molecules involved in these events, such as TGF-β1 and NOTCH1, are synthesized initially as inactive precursors and are proteolytically activated during T cell activation. PCSKs regulate proprotein maturation by catalyzing the proteolytic cleavage of their substrates. The prototype PCSK FURIN is induced upon TCR activation, and its expression in T  ...[more]

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