Dataset Information


Endogenous DAF-16 genome-wide recruitment under low Insulin signalling condition in Caenorhabditis elegans

ABSTRACT: In order to understand the complexity of gene regulation downstream of IIS, we did RNA-seq in mixed culture in wild-type, daf-2(e1370), daf-16(mgDf50);daf-2(e1370) and daf-2(e1370);daf-12(m20 and correlated it with ChIP-seq data RNA-seq profile of different mutants in mix stage

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Arnab Mukhopadhyay   Neeraj Kumar 

PROVIDER: E-GEOD-67975 | ArrayExpress | 2016-03-01



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Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans.

Kumar Neeraj N   Jain Vaibhav V   Singh Anupama A   Jagtap Urmila U   Verma Sonia S   Mukhopadhyay Arnab A  

Oncotarget 20151201 39

Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the first recruitment profile of endogenous DAF-16 and show that the response is conserved. DAF-16 predominantly acts as a transcriptional activator and binding within the 0.5 kb promoter-proximal region results in maximum induction of downstream targets that code for proteins inv  ...[more]

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