Transcriptomics

Dataset Information

239

EBV BART MicroRNAs Target Multiple Pro-apoptotic Cellular Genes to Promote Epithelial Cell Survival


ABSTRACT: Here, we report a systematic effort to identify pro-apoptotic mRNA targets for the EBV miR-BART miRNAs. We demonstrate that at least five of the 22 miR-BART pre-miRNAs have anti-apoptotic activity and we identify seven pro-apoptotic cellular mRNA targets, six of them novel, that contribute significantly to the observed anti-apoptotic phenotype. Together, these data represent a substantial increase in our understanding of the role of the miR-BART miRNAs in promoting EBV infection and latency. Use of deep sequencing to identify all the miRNAs expressed in C666 cells and PAR-CLIP to comprehensively profile EBV miRNA targets in C666 cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Rebecca L Skalsky   Bryan R Cullen  Dong Kang 

PROVIDER: E-GEOD-67990 | ArrayExpress | 2015-06-16

SECONDARY ACCESSION(S): SRP057301GSE67990PRJNA281456

REPOSITORIES: GEO, ArrayExpress, ENA

Similar Datasets

| GSE79571 | GEO
2010-10-01 | GSE22586 | GEO
2010-10-01 | E-GEOD-22586 | ArrayExpress
| GSE81528 | GEO
2009-02-07 | GSE14738 | GEO
2015-02-05 | E-GEOD-58723 | ArrayExpress
2014-08-01 | E-GEOD-58224 | ArrayExpress
2012-07-06 | E-GEOD-33225 | ArrayExpress
2009-02-07 | E-GEOD-14738 | ArrayExpress
| PRJNA281456 | ENA