Transcriptomics

Dataset Information

3

Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance


ABSTRACT: The nuclear orphan receptor Nur77 (NR4A1, TR3, or NGFI-B) has been shown to exhibit an anti-inflammatory function in macrophages. To further elucidate the role of Nur77 in macrophage physiology, we compared the transcriptome of bone marrow-derived macrophages (BMM) from wild-type (WT) and Nur77-knockout (KO) mice both before and after stimulation with IL4 or LPS. Comparison of gene expression in bone marrow-derived macrophages, isolated from 3 wild-type (control) and 3 Nur77-/- mice (case), left untreated or stimulated in triplicate for 8 hours with LPS or IL-4

ORGANISM(S): Mus musculus  

SUBMITTER: Perry D Moerland   Carlie J de Vries  Claudia M van Tiel  Anouk A Hamers 

PROVIDER: E-GEOD-68167 | ArrayExpress | 2016-03-01

SECONDARY ACCESSION(S): GSE68167PRJNA281927

REPOSITORIES: GEO, ArrayExpress

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