Genomics

Dataset Information

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NANOG metabolically reprograms tumor-initiating stem-like cells in oxidative phosphorylation and fatty acid metabolism


ABSTRACT: Stem cell markers such as NANOG have been implicated in various cancers; however, the functional contribution of NANOG to cancer pathogenesis has remained unclear. In the present study, we show that Toll-like receptor 4 (TLR4) signaling phosphorylates E2F1 to transactivate NANOG. Down-regulation of Nanog significantly reduces tumor development. In the search for the NANOG-dependent mechanisms underlying growth of tumor-initiating stem-like cells (TICs), NANOG ChIP-seq identifies the genes associated with mitochondrial metabolic pathways. Genome wide Identification of Nanog binding partners in tumor initating stem cells

ORGANISM(S): Mus musculus  

SUBMITTER: Dinesh B Kumar  Jun Xu   Chia-Lin Chen   Sonja Hess   Keigo Machida   Linda Sher   Vasu Punj    

PROVIDER: E-GEOD-68237 | ArrayExpress| 2016-01-17

SECONDARY ACCESSION(S): GSE68237SRP057636PRJNA282110

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.

Chen Chia-Lin CL   Uthaya Kumar Dinesh Babu DB   Punj Vasu V   Xu Jun J   Sher Linda L   Tahara Stanley M SM   Hess Sonja S   Machida Keigo K  

Cell metabolism 20151224 1


Stem cell markers, including NANOG, have been implicated in various cancers; however, the functional contribution of NANOG to cancer pathogenesis has remained unclear. Here, we show that NANOG is induced by Toll-like receptor 4 (TLR4) signaling via phosphorylation of E2F1 and that downregulation of Nanog slows down hepatocellular carcinoma (HCC) progression induced by alcohol western diet and hepatitis C virus protein in mice. NANOG ChIP-seq analyses reveal that NANOG regulates the expression of  ...[more]

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