Dataset Information


Transcription profiling of human and mouse cell lines under or over expressing human melanotransferrin

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE6815: Hyperexpression of Mouse Melanotransferrin on LMTK Cell Line; GSE6816: Hyperexpression of Human Melanotransferrin on SK-N-MC Cell Line; GSE6817: Downregulation of Human Melanotransferrin on SK-Mel-28 Cell Line Experiment Overall Design: Refer to individual Series

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Musculus  

SUBMITTER: Yohan Suryo Rahmanto  

PROVIDER: E-GEOD-6833 | ArrayExpress | 2008-06-15



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Identification of distinct changes in gene expression after modulation of melanoma tumor antigen p97 (melanotransferrin) in multiple models in vitro and in vivo.

Suryo Rahmanto Y   Dunn LL   Richardson DR  

Carcinogenesis 20070421 10

Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin. MTf is expressed at very low levels in normal tissues and in high amounts in melanoma cells although its function remains elusive. To understand the function of MTf, we utilized whole-genome microarray analysis to examine the gene expression profile of five models after modulating MTf expression. These models included two new stably transfected MTf hyper-expression model  ...[more]

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