Transcriptomics

Dataset Information

7

Temporal lobe epilepsy and Alzheimer's disease


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE6771: Temporal Cortex Control (mesial temporal lobe epilepsy control) GSE6773: Temporal neocortex mesial temporal lobe epilepsy GSE6774: Temporal Cortex Control (Alzheimer's disease control) GSE6775: Temporal Cortex Alzheimer's Disease GSE6777: Cerebellum Alzheimer's Disease GSE6778: Cerebellum Control (Alzheimer's disease control) Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Erin L. Heinzen  

PROVIDER: E-GEOD-6834 | ArrayExpress | 2007-01-23

SECONDARY ACCESSION(S): GSE6834PRJNA99163

REPOSITORIES: GEO, ArrayExpress

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Publications

Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease.

Heinzen Erin L EL   Yoon Woohyun W   Weale Michael E ME   Sen Arjune A   Wood Nicholas W NW   Burke James R JR   Welsh-Bohmer Kathleen A KA   Hulette Christine M CM   Sisodiya Sanjay M SM   Goldstein David B DB  

Genome biology 20070101 3


Alternative gene transcript splicing permits a single gene to produce multiple proteins with varied functions. Bioinformatic investigations have identified numerous splice variants, but whether these transcripts are translated to functional proteins and the physiological significance of these alternative proteins are largely unknown. Through direct identification of splice variants associated with disease states, we can begin to address these questions and to elucidate their roles in disease pre  ...[more]

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