Genomics

Dataset Information

3

Gene expression characterization of high and low grade clear cell renal cell carcinoma


ABSTRACT: Patients undergoing either partial or radical nephrectomy at William Beaumont Hospital (Royal Oak, MI) were consented prior to surgery with local IRB oversight. Samples were collected at time of surgery and stored at -80°C according to CAP (College of American Pathologist)-accredited standard operating procedures. Disease pathology of frozen samples was validated with hematoxylin and eosin stained tissue sections from adjacently collected formalin fixed paraffin embedded tissue. The objective of this study was to examine the gene expression patterns of clear cell carcinoma in relation to adjacent normal kidney as well as other benign kidney conditions. In particular, the goal was to identify gene expression that could differentiate high grade ccRCC from low grade ccRCC. Samples from patients with high grade ccRCC (Fuhrman grades 3 & 4, n=16) were compared to normal kidney samples (n=14) and also to samples from patients with benign kidney conditions (n=6). Samples from patients with low grade ccRCC (Fuhrman grades 1 & 2, n=13) were then also compared to normal kidney samples (n=14) and also to samples from patients with benign kidney conditions (n=6).

ORGANISM(S): Homo sapiens  

TISSUE(S): Normal Kidney, Renal Cyst, Clear Cell Renal Cell Carcinoma, Non-functional Kidney, Oncocytoma

SUBMITTER: Jason Hafron   Bryan Thibodeau  Matthew Fulton  Bryan J Thibodeau  George D Wilson  Laura E Fortier  Timothy J Geddes  Barbara L Pruetz 

PROVIDER: E-GEOD-68417 | ArrayExpress | 2016-01-04

SECONDARY ACCESSION(S): GSE68417PRJNA282671

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-68417.idf.txt Idf
E-GEOD-68417.processed.1.zip Processed
E-GEOD-68417.raw.1.zip Raw
E-GEOD-68417.raw.2.zip Raw
E-GEOD-68417.sdrf.txt Txt
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Publications

Characterization of clear cell renal cell carcinoma by gene expression profiling.

Thibodeau Bryan J BJ   Fulton Matthew M   Fortier Laura E LE   Geddes Timothy J TJ   Pruetz Barbara L BL   Ahmed Samreen S   Banes-Berceli Amy A   Zhang Ping L PL   Wilson George D GD   Hafron Jason J  

Urologic oncology 20151203 4


<h4>Objectives</h4>Use global gene expression to characterize differences between high-grade and low-grade clear cell renal cell carcinoma (ccRCC) compared with normal and benign renal tissue.<h4>Methods</h4>Tissue samples were collected from patients undergoing surgical resection for ccRCC. Affymetrix gene expression arrays were used to examine global gene expression patterns in high- (n = 16) and low-grade ccRCC (n = 13) as well as in samples from normal kidney (n =14) and benign kidney diseas  ...[more]

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