Transcriptomics

Dataset Information

6

Gene expressions specifically induced by the presence of SFB


ABSTRACT: To investigate SFB-host interactions and the host response to SFB, we compared gene expression profiles in terminal ileal mucosa collected from 5 SFB-positive and 5-negative age-matched patients identified from SFB PCR. We observed that 472 genes were different between the two groups (P < 0.05). Among them, 290 genes were up-regulated and 182 were down-regulated. GO biological pathway analysis of up-regulated genes revealed positive regulation of T-cell differentiation and activation pathways were enhanced (P < 0.001), suggesting that SFB colonization stimulated the human immune system, specifically T-cell maturation. Indeed, enhanced expression of Cd3e, Ifng, IL10, Foxp3 was observed in terminal ileal mucosa of 5 SFB-positive patients. To find immune-related genes significantly expressed (p < 0.05) between SFB-positive and -negative

ORGANISM(S): Homo sapiens  

SUBMITTER: Mizu Jiang   Wang Xin  Chen Bo  Li Jia  Chalie Xiang  chen bo 

PROVIDER: E-GEOD-68425 | ArrayExpress | 2015-05-01

SECONDARY ACCESSION(S): GSE68425PRJNA282712

REPOSITORIES: GEO, ArrayExpress

Similar Datasets

2012-01-01 | E-GEOD-30151 | ArrayExpress
2012-02-09 | E-GEOD-35610 | ArrayExpress
2012-02-09 | E-GEOD-35611 | ArrayExpress
2014-09-27 | E-GEOD-61788 | ArrayExpress
2012-11-06 | E-GEOD-42024 | ArrayExpress
2013-03-26 | E-GEOD-45501 | ArrayExpress
2014-02-13 | E-GEOD-54918 | ArrayExpress
2013-06-10 | E-GEOD-47764 | ArrayExpress
2015-04-07 | E-GEOD-37123 | ArrayExpress
2013-04-25 | E-GEOD-46337 | ArrayExpress