Transcriptomics

Dataset Information

6

CaArray_cho-00156: Gene Expression in Ovarian Cancer Reflects Both Morphology and Biological Behavior


ABSTRACT: Biologically and clinically meaningful tumor classification schemes have long been sought. Some malignant epithelial neoplasms, such as those in the thyroid and endometrium, exhibit more than one pattern of differentiation, each associated with distinctive clinical features and treatments. In other tissues, all carcinomas, regardless of morphological type, are treated as though they represent a single disease. To better understand the biological and clinical features seen in the four major histological types of ovarian carcinoma (OvCa), we analyzed gene expression in 113 ovarian epithelial tumors using oligonucleotide microarrays. Global views of the variation in gene expression were obtained using PCA. These analyses show that mucinous and clear cell OvCas can be readily distinguished from serous OvCas based on their gene expression profiles, regardless of tumor stage and grade. In contrast, endometrioid adenocarcinomas show significant overlap with other histological types. Although high-stage/grade tumors are generally separable from low-stage/grade tumors, clear cell OvCa has a molecular signature that distinguishes it from other poor-prognosis OvCas. Indeed, 73 genes, expressed 2- to 29-fold higher in clear cell OvCas compared with each of the other OvCa types, were identified. Collectively, the data indicate that gene expression patterns in ovarian adenocarcinomas reflect both morphological features and biological behavior. Moreover, these studies provide a foundation for the development of new type-specific diagnostic strategies and treatments for ovarian cancer. cho-00156 Assay Type: Gene Expression Provider: Affymetrix Array Designs: Hu6800 Organism: Homo sapiens (ncbitax) Material Types: synthetic_RNA, organism_part, whole_organism, total_RNA Disease States: Ovary cancer

ORGANISM(S): Homo sapiens  

SUBMITTER: Mervi Heiskanen  

PROVIDER: E-GEOD-68600 | ArrayExpress | 2015-05-07

SECONDARY ACCESSION(S): GSE68600PRJNA283195

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas.

Schwartz Donald R DR   Kardia Sharon L R SL   Shedden Kerby A KA   Kuick Rork R   Michailidis George G   Taylor Jeremy M G JM   Misek David E DE   Wu Rong R   Zhai Yali Y   Darrah Danielle M DM   Reed Heather H   Ellenson Lora H LH   Giordano Thomas J TJ   Fearon Eric R ER   Hanash Samir M SM   Cho Kathleen R KR  

Cancer research 20020801 16


Biologically and clinically meaningful tumor classification schemes have long been sought. Some malignant epithelial neoplasms, such as those in the thyroid and endometrium, exhibit more than one pattern of differentiation, each associated with distinctive clinical features and treatments. In other tissues, all carcinomas, regardless of morphological type, are treated as though they represent a single disease. To better understand the biological and clinical features seen in the four major histo  ...[more]

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