Dataset Information


ATF4 Licenses C/EBPb Activity in Human Mesenchymal Stem Cells Primed for Adipogenesis

ABSTRACT: We report ChIP-seq for C/EBPb and ATF4 in human mesenchymal stem cells and in a cell-free system using naked genomic DNA. ChIP-Seq for GR, RNA Polymerase II, and H3K27 acetylation in hMSCs cultured under different adipogenic conditions are also presented. hMSCs cultured at high or low cell seeding densities in the presence or absence of adipogenic induction cocktail

ORGANISM(S): Homo sapiens  

SUBMITTER: David Steger   Daniel Cohen  Daniel M Cohen 

PROVIDER: E-GEOD-68864 | ArrayExpress | 2015-06-25



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ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis.

Cohen Daniel M DM   Won Kyoung-Jae KJ   Nguyen Nha N   Lazar Mitchell A MA   Chen Christopher S CS   Steger David J DJ  

eLife 20150625

A well-established cascade of transcription factor (TF) activity orchestrates adipogenesis in response to chemical cues, yet how cell-intrinsic determinants of differentiation such as cell shape and/or seeding density inform this transcriptional program remain enigmatic. Here, we uncover a novel mechanism licensing transcription in human mesenchymal stem cells (hMSCs) adipogenically primed by confluence. Prior to adipogenesis, confluency promotes heterodimer recruitment of the bZip TFs C/EBPβ an  ...[more]

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