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Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mervi Heiskanen
PROVIDER: E-GEOD-68936 | ArrayExpress | 2015-05-24
SECONDARY ACCESSION(S): GSE68936PRJNA284137
REPOSITORIES: GEO, ArrayExpress
Staunton J E JE Slonim D K DK Coller H A HA Tamayo P P Angelo M J MJ Park J J Scherf U U Lee J K JK Reinhold W O WO Weinstein J N JN Mesirov J P JP Lander E S ES Golub T R TR
Proceedings of the National Academy of Sciences of the United States of America 20010901 19
In an effort to develop a genomics-based approach to the prediction of drug response, we have developed an algorithm for classification of cell line chemosensitivity based on gene expression profiles alone. Using oligonucleotide microarrays, the expression levels of 6,817 genes were measured in a panel of 60 human cancer cell lines (the NCI-60) for which the chemosensitivity profiles of thousands of chemical compounds have been determined. We sought to determine whether the gene expression signa ...[more]