Transcriptomics,Multiomics

Dataset Information

5

Tissue-specific changes in Tcrb conformation


ABSTRACT: We report the changes in Tcrb interactome upon transitioning from DN to DP stage of thymocyte development Examination of the interactomes of Eb and Trbv5 viewpoints in RAG-deficient DN and DP thymocytes

OTHER RELATED OMICS DATASETS IN: PRJNA284158

ORGANISM(S): Mus musculus  

SUBMITTER: Eugene M Oltz   Olivia I Koues  Kinjal Majumder 

PROVIDER: E-GEOD-68955 | ArrayExpress | 2015-07-08

SECONDARY ACCESSION(S): GSE68955SRP058393PRJNA284158

REPOSITORIES: GEO, ArrayExpress, ENA

Dataset's files

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E-GEOD-68955.idf.txt Idf
E-GEOD-68955.processed.1.zip Processed
E-GEOD-68955.sdrf.txt Txt
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Publications

Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development.

Majumder Kinjal K   Rupp Levi J LJ   Yang-Iott Katherine S KS   Koues Olivia I OI   Kyle Katherine E KE   Bassing Craig H CH   Oltz Eugene M EM  

Journal of immunology (Baltimore, Md. : 1950) 20150622 3


Considerable cross-talk exists between mechanisms controlling genome architecture and gene expression. AgR loci are excellent models for these processes because they are regulated at both conformational and transcriptional levels to facilitate their assembly by V(D)J recombination. Upon commitment to the double-negative stage of T cell development, Tcrb adopts a compact conformation that promotes long-range recombination between Vβ gene segments (Trbvs) and their DβJβ targets. Formation of a fun  ...[more]

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