Transcriptomics

Dataset Information

11

Transcription profiling by array of human HepG2 cells after treatment with 2,3-Dimethoxy-1,4-naphthoquinone, N-nitrosodimethylamine, phenol and six heavy metals


ABSTRACT: From the results of gene expression analyses of HepG2 under the exposure of 2,3-Dimethoxy-1,4-naphthoquinone (DMNQ), N-nitrosodimethylamine (DMN), phenol and six heavy metals We showed that biological action of six heavy metals were clearly related to that of DMNQ and distinguishable from the other chemicals. These results suggest that oxidative stress is major apparent biological action of high dose heavy metals, supporting the previous reports. Experiment Overall Design: Using Affymetrix HG-Focus arrays, we compared the gene expression patterns of Hep G2 cells induced by six heavy metals (As, Cd, Ni, Sb, Hg or Cr) with that of DMNQ, DMN or phenol, and evaluated the toxicities of these heavy metals.

REANALYSED by: E-GEOD-6907

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Koji Kawata  

PROVIDER: E-GEOD-6907 | ArrayExpress | 2009-04-08

SECONDARY ACCESSION(S): GSE6907PRJNA98519

REPOSITORIES: GEO, ArrayExpress

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Publications

Classification of heavy-metal toxicity by human DNA microarray analysis.

Kawata Koji K   Yokoo Hiroyuki H   Shimazaki Ryuhei R   Okabe Satoshi S  

Environmental science & technology 20070501 10


Microarray technology is proving to be a useful tool to classify undefined environmental toxicants, to investigate underlying mechanisms of toxicity, and to identify candidate toxicant-specific genetic markers by examining global effects of putative toxicants on gene expression profiles. The aim of this study was to evaluate the toxicities of six heavy metals through the comparison with gene expression patterns induced by well-known chemicals. For this purpose, we first identified the genes alte  ...[more]

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