Transcriptomics

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Role of histone demethylase LSD1 in hepatic cancer metabolism


ABSTRACT: Transcriptome analysis of LSD1-depleted HepG2 cells revealed that LSD1 regulates the expression of glycolytic and mitochondrial metabolism genes. We found that LSD1 is an important regulator of glycolysis and mitochondrial respiration in hepatoma. We depleted LSD1 in HepG2 human hepatoma cells using two different siRNAs, and then carried out an expression microarray experiment.

ORGANISM(S): Homo sapiens  

SUBMITTER: Shinjiro Hino   Akihisa Sakamoto  Mitsuyoshi Nakao 

PROVIDER: E-GEOD-69075 | ArrayExpress | 2015-05-21

SECONDARY ACCESSION(S): GSE69075PRJNA284489

REPOSITORIES: GEO, ArrayExpress

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