Transcriptomics

Dataset Information

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Short RNAs expression profiling in circulating CD34+ cells from Primary Myelofibrosis patients and from normal controls pooled bone marrow CD34+ cells.


ABSTRACT: We report the application of Illumina short RNA sequencing for characterization and discovery of miRNAs and moRNAs, and for identification of differentially expressed small RNAs in circulating CD34+ cells from Primary Myelofibrosis (PMF) patients and from normal controls pooled bone marrow CD34+ cells. Short RNAs sequencing for miRNA quantification, discovery and characterisation.

ORGANISM(S): Homo sapiens  

SUBMITTER: Alessandro Vannucchi  Stefania Bortoluzzi    

PROVIDER: E-GEOD-69089 | ArrayExpress | 2016-03-17

SECONDARY ACCESSION(S): SRP058531GSE69089PRJNA284504

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Small RNA Sequencing Uncovers New miRNAs and moRNAs Differentially Expressed in Normal and Primary Myelofibrosis CD34+ Cells.

Guglielmelli Paola P   Bisognin Andrea A   Saccoman Claudia C   Mannarelli Carmela C   Coppe Alessandro A   Vannucchi Alessandro M AM   Bortoluzzi Stefania S  

PloS one 20151015 10


Myeloproliferative neoplasms (MPN) are chronic myeloid cancers thought to arise at the level of CD34+ hematopoietic stem/progenitor cells. They include essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF). All can progress to acute leukemia, but PMF carries the worst prognosis. Increasing evidences indicate that deregulation of microRNAs (miRNAs) might plays an important role in hematologic malignancies, including MPN. To attain deeper knowledge of short RNAs (s  ...[more]

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