Transcriptomics

Dataset Information

3

Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia


ABSTRACT: We analyzed 52 Diagnostic samples from childhood Acute lymphoblastic leukemia samples We compared methylation profiles with four ALL cytogentic subtypes using (n=26) long term remission vs. (n=26) that went on to relapse

ORGANISM(S): Homo sapiens  

SUBMITTER: A S Gabriel   Alem Selassie Gabriel 

PROVIDER: E-GEOD-69229 | ArrayExpress | 2015-08-11

SECONDARY ACCESSION(S): GSE69229PRJNA284937

REPOSITORIES: GEO, ArrayExpress

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Publications


Although children with acute lymphoblastic leukemia (ALL) generally have a good outcome, some patients do relapse and survival following relapse is poor. Altered DNA methylation is highly prevalent in ALL and raises the possibility that DNA methylation-based biomarkers could predict patient outcome. In this study, genome-wide methylation analysis, using the Illumina Infinium HumanMethylation450 BeadChip platform, was carried out on 52 diagnostic patient samples from 4 genetic subtypes [ETV6-RUNX  ...[more]

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