Dataset Information


Renal Cell Carcinoma - Papillary types 1, and 2b, Normal Kidney Tissue

ABSTRACT: Myc oncogenic signature in Papillary type 2b Keywords: Gene Expression experiment Tumor samples compared to Normal renal tissue

ORGANISM(S): Homo sapiens  

SUBMITTER: Karl Dykema   Karl J Dykema 

PROVIDER: E-GEOD-7023 | ArrayExpress | 2007-06-12



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Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma.

Furge Kyle A KA   Chen Jindong J   Koeman Julie J   Swiatek Pamela P   Dykema Karl K   Lucin Kseniji K   Kahnoski Richard R   Yang Ximing J XJ   Teh Bin Tean BT  

Cancer research 20070401 7

Papillary renal cell carcinoma (RCC) represents 10% to 15% of adult renal neoplasms; however, the molecular genetic events that are associated with the development and progression of sporadic papillary RCC remain largely unclear. Papillary RCCs can be divided into two subtypes based on histologic, cytogenetic, and gene expression differences. Type 1 tumors ( approximately 60-70%) are generally low grade with favorable outcome, whereas type 2 tumors ( approximately 30-40%) are associated with inc  ...[more]

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