Transcriptomics

Dataset Information

5

The effect of progressive weight loss on metabolic function


ABSTRACT: The purpose of this study was to evaluate the effect of progressive weight loss (5, 10, 15% weight loss) on metabolic function such as multi-organ insulin sensitivity and beta-cell function in obese people. We conducted microarray analysis to determine the effect of progressive weight loss on adipose tissue gene expression profile. We examined subcuntaneous adipose tissue samples obtained from 9 obese subjects before (A) and after 5% (B), 10% (C) and 15% (D) weight loss (total 36 samples).

ORGANISM(S): Homo sapiens  

SUBMITTER: Jun Yoshino   Samuel Klein  Faidon Magkos 

PROVIDER: E-GEOD-70529 | ArrayExpress | 2016-02-26

SECONDARY ACCESSION(S): GSE70529PRJNA288954

REPOSITORIES: GEO, ArrayExpress

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Publications

Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.

Magkos Faidon F   Fraterrigo Gemma G   Yoshino Jun J   Luecking Courtney C   Kirbach Kyleigh K   Kelly Shannon C SC   de Las Fuentes Lisa L   He Songbing S   Okunade Adewole L AL   Patterson Bruce W BW   Klein Samuel S  

Cell metabolism 20160222 4


Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in  ...[more]

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