Genomics

Dataset Information

299

Genome-wide mapping of Hif-1α binding sites in zebrafish [ChIP-seq]


ABSTRACT: Analysis of the binding sites of Hif-1α in both wild-type and von Hippel Lindau mutant zebrafish lines at 4dpf by ChIP linked next generation sequencing. The von Hippel Lindau mutant displays a systemic hypoxic response under normoxic conditions. Results show the extent of Hif-1α binding to the genome, and provide a basis for analysis of the transcriptional response to genetically induced hypoxia in zebrafish. Analysis of the DNA binding sites of Hif-1α in both wild-type and von Hippel Lindau mutant zebrafish lines at 4dpf. The von Hippel Lindau mutant displays a systemic hypoxic response under normoxic conditions. Results show the extent of Hif-1α binding to the genome, and provide a basis for analysis of the dependency of the transcriptional response on Hif-1α in conditions of genetically induced hypoxia in zebrafish.

ORGANISM(S): Danio rerio  

SUBMITTER: David Greenald   Bernd Pelster  Justin Jeyakani Joseph Gnanakkan  Fredericus J van Eeden  Justin Jeyakani  Ian Sealy  Sinnakaruppan Mathavan 

PROVIDER: E-GEOD-70727 | ArrayExpress | 2016-03-22

SECONDARY ACCESSION(S): SRP060640GSE70727PRJNA289449

REPOSITORIES: GEO, ArrayExpress, ENA

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