Genomics,Multiomics

Dataset Information

2

Transcription profiling of rat chronic exposure to cigarette smoke


ABSTRACT: Chronic obstructive pulmonary disease is a smoking-related disease that lacks effective therapies due partly to the poor understanding of disease pathogenesis. The aim of this study was to identify molecular pathways which could be responsible for the damaging consequences of smoking. To do this, we employed recently described bioinformatic methods to analyze differences in global gene expression, which we then related to the pathological changes induced by cigarette smoke (CS). Sprague-Dawley rats were exposed to whole-body CS for 1 day and for various periods up to 8 months. Experiment Overall Design: Timecourse with 12 timepoints with 8 replicates at each time point.

OTHER RELATED OMICS DATASETS IN: PRJNA98491

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Christopher S. Stevenson 

PROVIDER: E-GEOD-7079 | ArrayExpress | 2008-06-15

SECONDARY ACCESSION(S): GSE7079PRJNA98491

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-7079.README.txt Txt
E-GEOD-7079.eSet.r Other
E-GEOD-7079.idf.txt Idf
E-GEOD-7079.processed.1.zip Processed
E-GEOD-7079.raw.1.zip Raw
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Publications

Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.

Stevenson Christopher S CS   Docx Cerys C   Webster Ruth R   Battram Cliff C   Hynx Debra D   Giddings June J   Cooper Philip R PR   Chakravarty Probir P   Rahman Irfan I   Marwick John A JA   Kirkham Paul A PA   Charman Christine C   Richardson Delwood L DL   Nirmala N R NR   Whittaker Paul P   Butler Keith K  

American journal of physiology. Lung cellular and molecular physiology 20070824 5


Chronic obstructive pulmonary disease (COPD) is a smoking-related disease that lacks effective therapies due partly to the poor understanding of disease pathogenesis. The aim of this study was to identify molecular pathways that could be responsible for the damaging consequences of smoking. To do this, we employed Gene Set Enrichment Analysis to analyze differences in global gene expression, which we then related to the pathological changes induced by cigarette smoke (CS). Sprague-Dawley rats we  ...[more]

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