Transcriptomics

Dataset Information

40

Gene expression profiling of SHSY5Y cells exposed to manganese


ABSTRACT: The trace element manganese is essential for normal development for all the organisms. Overexposure of manganese may leads to multiple neuronal disorders such as Parkinson, manganism. To explore the molecular mechanism of manganese induced neurotoxicity, gene expression profiling was performed on human neuroblastoma SHSY-5Y cells. Cells were exposed to sub-lethal concentration of manganese (100 μM) for 24 hrs. Our result demonstrates that manganese alter multiple biological pathways including chromatin assembly, neurogenesis and apoptotic pathways.Cells grown in 75mm2 flask. three replicates for each sample SHSY5Y cells grown in MEM:F12 media (1:1) were treated with manganese and total RNA was isolated from cells after 24 hour exposure Three replicate were used for the experiment

ORGANISM(S): Homo sapiens  

SUBMITTER: S S Devi   Pravin K Naoghare  Amit Bafana  Dr. saravana devi  Deepa Gandhi  K Krishnamurthi  Prashant Tarale 

PROVIDER: E-GEOD-70845 | ArrayExpress | 2016-07-01

SECONDARY ACCESSION(S): GSE70845PRJNA289673

REPOSITORIES: GEO, ArrayExpress

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