Transcriptomics

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Transcription profiling of human monocyte derived LPS-activated activated dendritic cells treated with IL-10


ABSTRACT: Gene expression profiels in the human monocyte-derived dendritic cells (DCs) from 4 different donors (A, B, C, and D) were studied. Cells were left untreated (Group 4), activated with LPS alone (Group 1) or activated in the presence cmv IL-10 (Group 2) or human IL-10 (Group 3) for 12 hours before subjected to RNA extraction. Experiment Overall Design: Overall ranscriptional profiles of activated DCs and IL-10-exposed activated DCs were compared with untreaetd immature DCs as baseline control.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: William Chang  

PROVIDER: E-GEOD-7095 | ArrayExpress | 2008-06-15

SECONDARY ACCESSION(S): GSE7095PRJNA98447

REPOSITORIES: GEO, ArrayExpress

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Publications

Exposure of myeloid dendritic cells to exogenous or endogenous IL-10 during maturation determines their longevity.

Chang W L William WL   Baumgarth Nicole N   Eberhardt Meghan K MK   Lee C Y Daniel CY   Baron Colin A CA   Gregg Jeff P JP   Barry Peter A PA  

Journal of immunology (Baltimore, Md. : 1950) 20070601 12


Dendritic cells (DC) are essential for the initiation of primary adaptive immune responses, and their functionality is strongly down-modulated by IL-10. Both innate and adaptive immune signals trigger the up-regulation of antiapoptotic Bcl-2 family members to facilitate the survival of DCs after maturation. However, whether IL-10 alters the expression of apoptotic-related genes in maturing DCs has not been determined. In this study, we demonstrate that spontaneous apoptosis rapidly occurred in m  ...[more]

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