Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE71019PRJNA290109
ORGANISM(S): Homo sapiens
SUBMITTER: Meng-Kang Wong Ruby-Yun-Ju Huang Julius Muller Tuan Zea Tan Tuan-Zea Tan Jean-Paul Thiery Ming Tan Kuee-Theng Kuay Vin-Yee Chung Zhe Yang Cheryl-Mei-Yi Koh Ernesto Guccione Jieru Ye
PROVIDER: E-GEOD-71017 | ArrayExpress | 2016-02-25
SECONDARY ACCESSION(S): GSE71017PRJNA290108
REPOSITORIES: GEO, ArrayExpress
Action | DRS | |||
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E-GEOD-71017.idf.txt | Idf | |||
E-GEOD-71017.processed.1.zip | Processed | |||
E-GEOD-71017.raw.1.zip | Raw | |||
E-GEOD-71017.sdrf.txt | Txt |
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Scientific reports 20160218
Epithelial-mesenchymal transition (EMT), a biological process by which polarized epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to the molecular heterogeneity of epithelial ovarian cancer (EOC). Here we report that a transcription factor--Grainyhead-like 2 (GRHL2) maintains the epithelial phenotype. EOC tumours with lower GRHL2 levels are associated with the Mes/Mesenchymal molecular subtype and a poorer overall survival. shRNA-mediated knockdown of GRHL ...[more]