Transcriptomics

Dataset Information

107

ADAR1-mediated A-to-I RNA editing is essential for erythropoiesis


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Alistair Morgan Chalk  

PROVIDER: E-GEOD-71047 | ArrayExpress | 2016-07-24

SECONDARY ACCESSION(S): GSE71047PRJNA290175

REPOSITORIES: GEO, ArrayExpress

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Publications


Adenosine deaminases that act on RNA (ADARs) convert adenosine residues to inosine in double-stranded RNA. In vivo, ADAR1 is essential for the maintenance of hematopoietic stem/progenitors. Whether other hematopoietic cell types also require ADAR1 has not been assessed. Using erythroid- and myeloid-restricted deletion of Adar1, we demonstrate that ADAR1 is dispensable for myelopoiesis but is essential for normal erythropoiesis. Adar1-deficient erythroid cells display a profound activation of inn  ...[more]

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