Dataset Information


Genome-wide RNA expression analysis of mouse spleens in parent-into-F1 lupus immune response

ABSTRACT: Analysis of whole spleen tissue expression signature in divergent responses from two parent-into-F1 lupus mouse model systems. The hypothesis is that strain differences of CD4 T cells exhibit difference lupus-inducing proclivity. Total RNA obtained from recipient mouse spleen at day 14 post-engraftment were profiled by Illumina BeadArray expression analysis

ORGANISM(S): Mus musculus  

SUBMITTER: Charles S Via   Clifton Lee Dalgard  Clifton L Dalgard 

PROVIDER: E-GEOD-71611 | ArrayExpress | 2015-09-02



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Intrinsic Differences in Donor CD4 T Cell IL-2 Production Influence Severity of Parent-into-F1 Murine Lupus by Skewing the Immune Response Either toward Help for B Cells and a Sustained Autoantibody Response or toward Help for CD8 T Cells and a Downregulatory Th1 Response.

Soloviova Kateryna K   Puliaiev Maksym M   Haas Mark M   Dalgard Clifton L CL   Schaefer Brian C BC   Via Charles S CS  

Journal of immunology (Baltimore, Md. : 1950) 20150828 7

Using the parent-into-F1 model of induced lupus and (C57BL/6 × DBA2) F1 mice as hosts, we compared the inherent lupus-inducing properties of the two parental strain CD4 T cells. To control for donor CD4 recognition of alloantigen, we used H-2(d) identical DBA/2 and B10.D2 donor T cells. We demonstrate that these two normal, nonlupus-prone parental strains exhibit two different T cell activation pathways in vivo. B10.D2 CD4 T cells induce a strong Th1/CMI pathway that is characterized by IL-2/IFN  ...[more]

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